叶丽林教授现任中国细胞生物学学会免疫细胞生物学分会秘书长，长期从事病毒免疫学、肿瘤免疫学及传染病相关研究，新冠肺炎疫情发生后，他积极投身新冠科研任务，在基础研究、疫苗研发方面取得重大成果，世界首次研发出具有预防及治疗潜力的新冠病毒中和抗体（CMI, 2020, 17:647-649;STTT, 2020.09.5:180），为疫情防控作出重大贡献。叶丽林教授是科技部973项目首席科学家（2013），国家杰青（2018），万人计划科技领军人才（2019）；主持或参与完成多项重大科研项目，入选国家创新人才推进计划中青年科技创新领军人才（2016），重庆市“百人计划”（2015），首届重庆市十佳科技青年奖（2015）；2012年授权美国专利1项，2017年申请国家专利1项；2016年获药明康德生命化学学者奖，2018年重庆市自然科学一等奖(5)，2020年重庆市自然科学一等奖(1),2021年获得第二十三届中国科协求是杰出青年奖；以通讯作者发表影响因子20分以上论文多篇，包括Nature, Nature medicine, Nature Immunology, Immunity等, 最高影响因子43.1，研究成果入选“ESI高引论文”、“中国百篇卓越论文”、“中国百篇最具国际影响力论文”等。

    病毒免疫学及肿瘤免疫学，重点研究T细胞应答在慢性病毒感染及肿瘤的发生、发展及转移中的关键作用以及改造、修饰及诱导T细胞用于慢性病毒感染及肿瘤的免疫治疗。

1.Yu D, Ye L*.A Portrait of CXCR5+ Follicular Cytotoxic CD8+ T cells.Trends Immunol. 2018 Dec;39(12):965-979. doi: 10.1016/j.it.2018.10.002. (*Corresponding author) （IF=14.178；JCR分区1区）

2.Zhao L, He R, Long H, Guo B, Jia Q, Tan Y, Xiang T, Zhang J, Hu C, Gao J, Yang X, Zeng H, Wang X, Huang J, Symonds A,LJ, , Wan Y, Li Q, Ye L*, Zhu B. CD45⁺CD71⁺TER119⁺ erythroid progenitor cells derived from tumor-bearing hosts suppress the CD8⁺ T cell response via the ROS pathway. Nat Medicine. 2018. 24:1536-1544. (*Corresponding author) （IF=32.621；JCR分区1区）

3. Huang Q, Hu J, Tang J, Xu L, Ye L*. Molecular Basis of the Differentiation and Function of Virus Specific Follicular Helper CD4+ T Cells. Front Immunol. 2019 Feb 15;10:249. doi: 10.3389/fimmu.2019.00249. eCollection 2019(*Corresponding author) （IF=5.511；JCR分区2区）

4. Wang P, Wang Y, Xie L, Xiao M, Wu J,Xu L, Bai Q, Hao Y, Huang Q, Chen X, He R , Li  B,Yang S, Chen Y , Wu Y  and Ye L *.The Transcription Factor T-Bet Is Required for Optimal Type I Follicular Helper T Cell Maintenance During Acute Viral Infection. Front Immunol.2019 Mar 29; 10:606. doi: 10.3389/fimmu.2019.00606. eCollection 2019 (*Corresponding author) （IF=5.511；JCR分区2区）

5. Wang Y, Hu J, Li Y, Xiao M, Wang H, Tian Q, Li Z, Tang J, Hu L, Tan Y, Zhou X, He R, Wu Y, Ye L *, Yin Z, Huang Q, Xu L. The Transcription Factor TCF1 Preserves the Effector Function of Exhausted CD8 T Cells During Chronic Viral Infection. Front Immunol. 2019 Feb 12;10:169. doi: 10.3389/fimmu.2019.00169. eCollection 2019(*Corresponding author) （IF=5.511；JCR分区2区）

6.Chen X, Ye L*. B7S1, a novel candidate for anti-tumor checkpoint blockade immunotherapy. Sci China Life Sci. 2018 Jun 21. doi: 10.1007/s11427-018-9321-0. (*Corresponding author) （IF=3.1；JCR分区1区）

7.Hao Y, Wang Y, Liu X, Yang X, Wang P, Tian Q, Bai Q, Chen X, Li Z, Wu J, Xie Z, Zhou X, Zhou Y, Yin Z, Wu Y, Ye L*. The Kinase Complex mTOR Complex 2 Promotes the Follicular Migration and Functional Maturation of Differentiated Follicular Helper CD4+ T Cells During Viral Infection. Front Immunol. 2018 May 23;9:1127. doi: 10.3389/fimmu.2018.01127. eCollection 2018. (*Corresponding author) （IF=5.511；JCR分区2区）

8.Xiao M, Chen X, He R, Ye L*. Differentiation and Function of Follicular CD8 T Cells During Human Immunodeficiency Virus Infection. Front Immunol. 2018 May 22;9:1095. doi: 10.3389/fimmu.2018.01095. eCollection 2018. (*Corresponding author) （IF=5.511；JCR分区2区）

9.Hao Y, Li Z, Wang Y, Liu X, Ye L*. Analyzing Mouse B Cell Responses Specific to LCMV Infection. Methods Mol Biol. 2018;1707:15-38. doi: 10.1007/978-1-4939-7474-0_2. (*Corresponding author)

10.Huang Q, Wang H, Xu L, Hu J, Wang P, Li Y, Ye L*. Flow Cytometry Analyzing Mtor Signaling in Antigen-Specific B Cells. Methods Mol Biol. 2018; 1707:95-109. doi: 10.1007/978-1-4939-7474-0_7. (*Corresponding author)

11.Xu L, Huang Q, Wang H, Hao Y, Bai Q, Hu J, Li Y, Wang P, Chen X, He R, Li B, Yang X, Zhao T, Zhang Y, Wang Y, Ou J, Liang H, Wu Y, Zhou X, Ye L*. The Kinase mTORC1 Promotes the Generation and Suppressive Function of Follicular Regulatory T Cells. Immunity. 2017 Sep 19;47(3):538-551.e5. doi: 10.1016/j.immuni.2017.08.011. (*Corresponding author) （IF=22.845；JCR分区1区）

12.Chen X, Zhang D, Chen X, Meng G, Zheng Q, Mai W, Wu Y, Ye L*, Wang L. Oral administration of visceral adipose tissue antigens ameliorates metabolic disorders in mice and elevates visceral adipose tissue-resident CD4⁺CD25⁺Foxp3⁺ regulatory T cells. Vaccine. 2017 Aug 16;35:4612-4620. doi: 10.1016/j.vaccine.2017.07.014. (*Corresponding author) （IF=3.285；JCR分区2区）

13.He R, Yang X, Liu C, Chen X, Wang L, Xiao M, Ye J, Wu Y, Ye L*. Efficient control of chronic LCMV infection by a CD4 T cell epitope-based heterologous prime-boost vaccination in a murine model. Cell Mol Immunol. 2017 Mar 13. doi: 10.1038/cmi.2017.3. (*Corresponding author) （IF=8.484；JCR分区1区）

14.Ye L, Lee J, Xu L, Mohammed AU, Li W, Hale JS, Tan WG, Wu T, Davis CW, Ahmed R, Araki K. mTOR Promotes Antiviral Humoral Immunity by Differentially Regulating CD4 Helper T Cell and B Cell Responses. J Virol. 2017 Jan 31;91(4). pii: e01653-16. doi: 10.1128/JVI.01653-16. （IF=4.663；JCR分区2区）

15.He R, Hou S, Liu C, Zhang A, Bai Q, Han M, Yang Y, Wei G, Shen T, Yang X, Xu L, Chen X, Hao Y, Wang P, Zhu C, Ou J, Liang H, Ni T, Zhang X, Zhou X, Deng K, Chen Y, Luo Y, Xu J, Qi H, Wu Y, Ye L*. Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection. Nature. 2016 Aug 2;537(7620):412-428. doi: 10.1038/nature19317. (*Corresponding author) （IF=40.137；JCR分区1区）

16.Xu L, Cao Y, Xie Z, Huang Q, Bai Q, Yang X, He R, Hao Y, Wang H, Zhao T, Fan Z, Qin A, Ye J, Zhou X, Ye L*, Wu Y. The transcription factor TCF-1 initiates the differentiation of TFH cells during acute viral infection. Nat Immunol. 2015 Sep;16(9):991-9. doi: 10.1038/ni.3229. (*Corresponding author) （IF=21.506；JCR分区1区）

17.Ye L, Zeng R, Bai Y, Roopenian DC, Zhu X. Efficient mucosal vaccination mediated by the neonatal Fc receptor. Nat Biotechnol.2011 Feb;29(2):158-63. doi: 10.1038/nbt.1742. （IF=41；JCR分区1区）

18. Chen X, Li R, Pan Z, Qian C, Yang Y, You R, Zhao J, Liu P, Gao L, Li Z, Huang Q, Xu L, Tang J, Tian Q, Yao W, Hu L, Yan X, Zhou X, Wu Y, Deng K, Zhang Z, Qian Z, Chen Y, Ye L. Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor. Cell Mol Immunol. 2020 Jun;17(6):647-649. doi: 10.1038/s41423-020-0426-7. （IF=8.484；JCR分区1区）

19. Chen X, Cao G, Wu J, Wang X, Pan Z, Gao J, Tian Q, Xu L, Li Z, Hao Y, Huang Q, Wang P, Xiao M, Xie L, Tang S, Liu Z, Hu L, Tang J, He R, Wang L, Zhou X, Wu Y, Chen M, Sun B, Zhu B, Huang J, Ye L. The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection. Cell Mol Immunol. 2020 Mar;17(3):247-260. doi: 10.1038/s41423-019-0219-z.（IF=8.484；JCR分区1区）

20. Chen X, Pan Z, Yue S, Yu F, Zhang J, Yang Y, Li R, Liu B, Yang X, Gao L, Li Z, Lin Y, Huang Q, Xu L, Tang J, Hu L, Zhao J, Liu P, Zhang G, Chen Y, Deng K, Ye L. Disease severity dictates SARS-CoV-2-specific neutralizing antibody responses in COVID-19. Signal Transduct Target Ther. 2020 Sep 2;5(1):180. doi: 10.1038/s41392-020-00301-9.（IF=13.493；JCR分区1区）

21. Leiqiong Gao, Jing Zhou, Sen Yang, Lisha Wang, Xiangyu Chen, Yang Yang, Ren Li, Zhiwei Pan, Jing Zhao, Zhirong Li, Qizhao Huang, Jianfang Tang, Li Hu, Pinghuang Liu, Guozhong Zhang, Yaokai Chen and Lilin Ye. The dichotomous and incomplete adaptive immunity in COVID-19 patients with different disease severity. Signal Transduct Target Ther.2021 Mar8; 6(1): p.113. doi.org/10.1038/s41392-021-00525-3.（IF=13.493；JCR分区1区）