2011年于中山大学获得生化与分子生物学博士学位，其后在美国德克萨斯大学MD安德森癌症中心神经外科系从事研究工作近7年，先后任博士后和讲师（Instructor)，主要从事原发胶质母细胞瘤以及肺癌/乳腺癌脑转移分子机制以及新的靶向药物的开发和转化研究。2018年底以高层人才引进至南方医科大学，并组建肿瘤分子生物学研究平台。以通讯作者或第一作者在Nat cell Biol、 JCI、PNAS、Adv Sci, Sci Adv、Cancer Res、Oncogene、Embo Rep等杂志发表研究论文，被引用2500 余次（Google scholar, 包括被Science、Cell、Nat Med等期刊）。是中国神经学会神经肿瘤分会委员、广东省精准医学会神经肿瘤分会常务委员，受邀在国内外多个会议进行会议报告，同时是Nat Commun、Cancer Research等十几种领域内知名期刊的评审专家，以及国自然面上项目、青年项目、博士后基金评审专家。

（1）胶质母细胞瘤放/化疗耐药的细胞和分子基础；

（2）以胶质母细胞瘤为模型，研究肿瘤微环境与肿瘤细胞的应答机制及其在肿瘤耐药和复发中的作用；

（3）肺癌/乳腺癌脑转移的分子机制，以及新型干预药物的开发。

1. Yu Zeng, Liqian Zhao, Kunlin Zeng, Ziling Zhan, Zhengming Zhan, Shangbiao Li, Hongchao Zhan, Peng Chai, Cheng Xie, Shengfeng Ding, Yuxin Xie, Li Wang, Cuiying Li, Xiaoxia Chen, Daogang Guan, Enguang Bi, Jianyou Liao, Fan Deng, Xiaochun Bai, Ye Song, Aidong Zhou*. TRAF3 Loss Protects Glioblastoma Cells from Lipid Peroxidation and Immune Elimination via Dysregulated Lipid Metabolism. J Clin Invest, 2025 Feb 11;135(7):e178550. (最后通讯，I区，IF=13.6; 同期JCI对该论文重点评述）

2. Wang L, Li C, Zhan H, Li S, Zeng K, Xu C, Zou Y, Xie Y, Zhan Z, Yin S, Zeng Y, Chen X, Lv G, Han Z, Zhou D, Zhou D, Yang Y, Zhou A*. Targeting the HSP47-collagen axis inhibits brain metastasis by reversing M2 microglial polarization and restoring anti-tumor immunity. Cell Rep Med. 2024 May 21;5(5):101533.（最后通讯，I区，IF=11.7）

3. Kunlin Zeng, Yu Zeng, Hongchao Zhan, Ziling Zhan, Li Wang, Yuxin Xie, Yanqing       Tang, Cuiying Li, Yanwen Chen, Shangbiao Li, Ming Liu, Xiaoxia Chen, Li Liang, Fan Deng, Ye Song, Aidong Zhou*. SEC61G assists EGFR-amplified glioblastoma to evade immune elimination. PNAS, 2023 Aug 8;120(32):e2303400120. (独立通讯，I区，IF=11.1；同期PNAS对该论文重点评述）

4. Li S, Chen Y, Xie Y, Zhan H, Zeng Y, Zeng K, Wang L, Zhan Z, Li C, Zhao L, Chen X, Tan Y, Wang Z, Bu J, Song Y, Deng F, Zhou A*. FBXO7 Confers Mesenchymal Properties and Chemoresistance in Glioblastoma by Controlling Rbfox2-Mediated Alternative Splicing. Adv Sci (Weinh). 2023 Nov;10(33):e2303561.(独立通讯，I区，IF=15.1）

5. Zelong Han, Ming Liu, Yuxin Xie, Kunlin Zeng, Ziling Zhan, Yanwen Chen, Li Wang, Xiaoxia Chen, Yaxin Luo, Yu Zeng, Hongchao Zhan, Yingzhuo Lin, Keqin Zhang, Xiaoxia Zhu, Side Liu, Xiaobei Luo*, Aidong Zhou*. Derepression of the USP22-FASN axis by p53 loss under oxidative stress drives lipogenesis and tumorigenesis.Cell Death Discov. 2022 Nov 4;8(1):445. (最后通讯，II区，IF=7.0）

6. Li Ma, Kangyu Lin, Guoqiang Chang, Yiwen Chen, Chen Yue, Qing Guo, Sicong Zhang, Zhiliang Jia, Tony T Huang, Aidong Zhou*, Suyun Huang*. Aberrant activation of β-catenin signaling drives glioma tumorigenesis via USP1-mediated stabilization of EZH2. Cancer Res, 2019 Jan 1;79(1):72-85. (共同通讯，I区，IF=16.6）

7. Linlin Li, Aidong Zhou, Yanjun Wei, Feng Liu, Peng Li, Runping Fang, Li Ma, Sicong Zhang, Longqiang Wang, Jinze Liu, Hope T Richard, Yiwen Chen, Hengbin Wang, Suyun Huang. Critical role of lncEPAT in coupling dysregulated EGFR pathway and histone H2A deubiquitination during glioblastoma tumorigenesis, Sci Adv, 2022, 8(40): :eabn2571. (共同一作，I区，IF=14.9）

8. Aidong Zhou, Kangyu Lin, Sicong Zhang, Yaohui Chen, Nu Zhang, Jianfei Xue, Zhongyong Wang, Kenneth D Aldape, Keping Xie, James R Woodgett, Suyun Huang. High-level nuclear GSK3β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitination by USP22. Nat Cell Biol. 2016 Sep;18(9):954-66. (一作，I区，IF=20.1；Transl Cancer Res等期刊重点评述）

9. Aidong Zhou, Kangyu Lin, Sicong Zhang, Li Ma, Jianfei Xue, Saint-Aaron Morris, Kenneth D Aldape, Suyun Huang. Gli1-induced deubiquitinase USP48 promotes glioma tumorigenesis by deubiquitinating and stabilizing Gli1. EMBO Rep (2017) 18, 1318-1330. (一作，I区；IF=8.6）