目录
更新日期:2025年9月28日
姓 名 王继德 性 别
民 族 汉族 导师层次 博士导师
技术职称 教授 导师类型 学术&专业型
最后学历 博士研究生毕业 最后学位 医学博士学位
行政职务 其他 Email jidewang55@163.com
工作单位 南方医科大学南方医院 邮政编码 510515
个人简介

长期从事胃肠肿瘤的临床及基础研究,前后承担多项国家及省级研究项目,熟悉相关领域的前沿研究,积累了较多的研究方法和实验材料,有较为扎实的工作基础。曾作为项目参与人获得2009年度国家科技进步一等奖、1998年度国家科技进步二等奖、1997年度及2004年度军队科技进步二等奖、2018年度广东省科学技术奖一等奖、2012年度广东省科学技术奖二等奖等奖项。曾作为编委参与编著《分子生物学常用实验方法》及《幽门螺杆菌的基础与临床》。学术任职方面,曾任中华医学会消化分会中青年委员会:副主任委员、中华医学会消化分会幽门螺杆菌学组暨全国幽门螺杆菌科研协作组:副组长、中华预防医学会微生态学会:委员及临床学组副组长、广东消化学会:常委、广东省消化医师工作委员会:常委、广东省中西医结合学会中青年工作委员会:常委。曾作为第一作者或第一通讯作者在国际知名胃肠病和肿瘤学期刊发表论文,如Gastroenterology, Nat Commun,Cancer Lett,Cell Death Dis,Oncogenesis 和 J Exp Clin Cancer Res. 等,共计以第一作者或第一通讯作者发表SCI超30篇。主持国家自然科学基金面上项目6项;并多次主持或参与广东省重大社会科技计划项目、广东省自然科学基金、南方医院院长基金等研究项目。

研究领域

胃肠肿瘤、增殖转移、转录因子、miRNA、LncRNA、假基因

个人成果

发表论文:


1. Zhang J, Wei X, Xie Y, Peng S, Yang P, Chen Y, Huang X, Wu J, Hong L, Guo Z, Huang X, Lin Z, Zhi F, Liu S, Xiang L, Lin J, Li A, Wang J. Long non-coding RNA-MIR181A1HG acts as an oncogene and contributes to invasion and metastasis in gastric cancer. Oncogene. 2025 Jun;44(20):1517-1529.
2. Pei M, Zhang J, Yu Z, Peng Y, Chen Y, Peng S, Wei X, Wu J, Huang X, Xie Y, Yang P, Hong L, Huang X, Wu X, Tang W, Chen Y, Liu S, Lin J, Xiang L, Wang J. LINC02139 interacts with and stabilizes XIAP to regulate cell proliferation and apoptosis in gastric cancer. Commun Biol. 2024 Nov 12;7(1):1497.
3. Xiao Y, Yang P, Xiao W, Yu Z, Li J, Li X, Lin J, Zhang J, Pei M, Hong L, Yang J, Lin Z, Jiang P, Xiang L, Li G, Ai X, Dai W, Tang W, Wang J. POU2F1 Inhibits miR-29b1/a Cluster-Mediated Suppression of PIK3R1 and PIK3R3 Expression to Regulate Gastric Cancer Cell Invasion and Migration. Chin Med J (Engl) 2024.
4. Li J, Yang P, Hong L, Xiao W, Zhang L, Yu Z, Zhang J, Pei M, Peng Y, Wei X, Wu X, Tang W, Zhao Y, Yang J, Lin Z, Jiang P, Xiang L, Zhang H, Lin J, Wang J. BST2 Promotes Gastric Cancer Metastasis under the Regulation of HOXD9 and PABPC1. Mol Carcinog 2024, 63 (4), 663–676.
5. Pei M, Xu N, Li J, Liu X, Zhang L, Xiao W, Yu Z, Yang P, Peng Y, Zhang J, Hong L, Wu X, Tang W, Lin Z, Zhi F, Li G, Li A, Liu S, Chen Y, Xiang L, Lin J, Wang J. The LINC00501-HSP90B1-STAT3 Positive Feedback Loop Promotes Malignant Behavior in Gastric Cancer Cells. Cell Signal 2023, 108, 110711. (IF=4.4)
6. Li J, Pei M, Xiao W, Liu X, Hong L, Yu Z, Peng Y, Zhang J, Yang P, Lin J, Wu X, Lin Z, Tang W, Zhi F, Li G, Xiang L, Li A, Liu S, Chen Y, Wang J. The HOXD9-Mediated PAXIP1-AS1 Regulates Gastric Cancer Progression through PABPC1/PAK1 Modulation. Cell Death Dis 2023, 14 (5), 341. (IF=8.1)
7. Hong L, Yang P, Zhang L, Liu X, Wei X, Xiao W, Yu Z, Zhang J, Peng Y, Wu X, Tang W, Zhi F, Li G, Li A, Lin J, Liu S, Zhang H, Xiang L, Wang J. The VAX2-LINC01189-hnRNPF Signaling Axis Regulates Cell Invasion and Migration in Gastric Cancer. Cell Death Discov 2023, 9 (1), 387. (IF=6.1)
8. Dai W, Hong L, Xiao W, Zhang L, Sha W, Yu Z, Liu X, Liu S, Xiao Y, Yang P, Peng Y, Zhang J, Lin J, Wu X, Tang W, Lin Z, Xiang L, Li J, Pei M, Wang J. The ATF2/miR-3913-5p/CREB5 Axis Is Involved in the Cell Proliferation and Metastasis of Colorectal Cancer. Commun Biol 2023, 6 (1), 1026. (IF=5.2)
9. Yu G, Zhou L, Liu X, Liu B, Lai X, Xu C, Long M, Zhu Y, Wang J, Li M. Therapeutic Effect of Indirubin-Loaded Bovine Serum Albumin Nanoparticules on Ulcerative Colitis. Biomater Sci 2022, 10 (9), 2215–2223. (IF=6.6)
10. Tang W, Pei M, Li J, Xu N, Xiao W, Yu Z, Zhang J, Hong L, Guo Z, Lin J, Dai W, Xiao Y, Wu X, Liu G, Zhi F, Li G, Xiong J, Chen Y, Zhang H, Xiang L, Li A, Liu S, Wang J. The miR-3648/FRAT1-FRAT2/c-Myc Negative Feedback Loop Modulates the Metastasis and Invasion of Gastric Cancer Cells. Oncogene 2022, 41 (43), 4823–4838. (IF=8)
11. Chen Y, Pei M, Li J, Wang Z, Liu S, Xiang L, Zhang J, Hong L, Lin J, Dai W, Xiao Y, Hu H, Tang W, Liu G, Yang Q, Lin Z, Jiang X, Wang Y, Wu X, Guo Z, Wang J. Disruption of the CCDC43-FHL1 Interaction Triggers Apoptosis in Gastric Cancer Cells. Exp Cell Res 2022, 415 (1), 113107. (IF=3.7)
12. Wu X, Wang H, Zhu D, Chai Y, Wang J, Dai W, Xiao Y, Tang W, Li J, Hong L, Pei M, Zhang J, Lin Z, Wang J, Li A, Liu S. USP3 promotes gastric cancer progression and metastasis by deubiquitination-dependent COL9A3/COL6A5 stabilisation. Cell Death Dis. 13(1):10. (IF=8.469)
13. Dai W, Wang J, Wang Z, Xiao Y, Li J, Hong L, Pei M, Zhang J, Yang P, Wu X, Tang W, Jiang X, Jiang P, Xiang L, Li A, Lin J, Liu S, Wang J. Comprehensive Analysis of the Prognostic Values of the TRIM Family in Hepatocellular Carcinoma. Front Oncol. 11:767644.  (IF=6.244)
14. Dai W, Liu S, Zhang J, Pei M, Xiao Y, Li J, Hong L, Lin J, Wang J, Wu X, Liu G, Chen Y, Wang Y, Lin Z, Yang Q, Zhi F, Li G, Tang W, Li A, Xiang L, Wang J. Vorinostat triggers miR-769-5p/3p-mediated suppression of proliferation and induces apoptosis via the STAT3-IGF1R-HDAC3 complex in human gastric cancer. Cancer Lett. 521:196-209. (IF=8.679)
15. Dai W, Xiao Y, Tang W, Li J, Hong L, Zhang J, Pei M, Lin J, Liu S, Wu X, Xiang L, Wang J. Identification of an EMT-Related Gene Signature for Predicting Overall Survival in Gastric Cancer. Front Genet. 12:661306. (IF=4.599)
16. Yang Q, Wang Y, Li M, Wang Z, Zhang J, Dai W, Pei M, Hong L, Xiao Y, Hu H, Li J, Lin J, Wu X, Chen Y, Huang M, Li A, Liu S, Tang W, Xiang L, Wang J. HMGA1 promotes gastric cancer growth and metastasis by transactivating SUZ12 and CCDC43 expression. Aging (Albany NY). 13(12):16043-16061. (IF=5.682)
17. Lin J, Zhu H, Hong L, Tang W, Wang J, Hu H, Wu X, Chen Y, Liu G, Yang Q, Li J, Wang Y, Lin Z, Xiao Y, Dai W, Huang M, Li G, Li A, Wang J, Xiang L, Liu S. Coexpression of HOXA6 and PBX2 promotes metastasis in gastric cancer. Aging (Albany NY). 2021; 13(5):6606-6624. (IF=5.682)
18. Tang W, Hong L, Dai W, Li J, Zhu H, Lin J, Yang Q, Wang Y, Lin Z, Liu M, Xiao Y, Zhang Y, Wu X, Wang J, Chen Y, Hu H, Liu S, Wang J, Xiang L. MicroRNA‑500a‑5p inhibits colorectal cancer cell invasion and epithelial‑mesenchymal transition. Int J Oncol. 2020; 56(6):1499-1508. (IF=5.650)
19. Liu M, Xiao Y, Tang W, Li J, Hong L, Dai W, Zhang W, Peng Y, Wu X, Wang J, Chen Y, Bai Y, Lin J, Yang Q, Wang Y, Lin Z, Liu S, Xiong J, Wang J, Xiang L. HOXD9 promote epithelial-mesenchymal transition and metastasis in colorectal carcinoma. Cancer Med. 2020 Apr 12. (IF=4.452)
20. Wang J, Wu X, Dai W, Li J, Xiang L, Tang W, Lin J, Zhang W, Liu G, Yang Q, Lin Z, Sun Y, Zhang Y, Chen Y, Li G, Li A, Liu S, Li Y, Wang J. The CCDC43-ADRM1 axis regulated by YY1, promotes proliferation and metastasis of gastric cancer. Cancer Lett. 2020. 482:90-101. (IF=8.679)
21. Zhu H, Dai W, Li J, Xiang L, Wu X, Tang W, Chen Y, Yang Q, Liu M, Xiao Y, Zhang W, Lin J, Wang J, Liu G, Sun Y, Jiang P, Li G, Li A, Liu S, Chen Y, Wang J. HOXD9 promotes the growth, invasion and metastasis of gastric cancer cells by transcriptional activation of RUFY3. J Exp Clin Cancer Res. 2019; 38(1): 412. (IF=11.161)
22. Wu X, Liu M, Zhu H, Wang J, Dai W, Li J, Zhu D, Tang W, Xiao Y, Lin J, Zhang W, Sun Y, Zhang Y, Chen Y, Li G, Li A, Xiang L, Liu S, Wang J. Ubiquitin-specific protease 3 promotes cell migration and invasion by interacting with and deubiquitinating SUZ12 in gastric cancer. J Exp Clin Cancer Res. 2019; 38(1):277. (IF=11.161)
23. Tang W, Zhou W, Xiang L, Wu X, Zhang P, Wang J, Liu G, Zhang W, Peng Y, Huang X, Cai J, Bai Y, Bai L, Zhu W, Gu H, Xiong J, Ye C, Li A, Liu S, Wang J. The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer. Nat Commun. 2019; 10(1):663.(IF=14.919)
24. Zhang H, Wu X, Xiao Y, Wu L, Peng Y, Tang W, Liu G, Sun Y, Wang J, Zhu H, Liu M, Zhang W, Dai W, Jiang P, Li A, Li G, Xiang L, Liu S, Wang J. Coexpression of FOXK1 and vimentin promotes EMT, migration, and invasion in gastric cancer cells. J Mol Med (Berl). 2019 ;97(2):163-176. (IF=4.599)
25. Wang J, Liu G, Liu M, Xiang L, Xiao Y, Zhu H, Wu X, Peng Y, Zhang W, Jiang P, Li A, Nan Q, Chen Y, Chen C, Cheng T, Liu S, Wang J. The FOXK1-CCDC43 Axis Promotes the Invasion and Metastasis of Colorectal Cancer Cells. Cell Physiol Biochem. 2018; 51(6):2547-2563.
26. Huang X, Xiang L, Li Y, Zhao Y, Zhu H, Xiao Y, Liu M, Wu X, Wang Z, Jiang P, Qing H, Zhang Q, Liu G, Zhang W, Li A, Chen Y, Liu S, Wang J. Snail/FOXK1/Cyr61 Signaling Axis Regulates the Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer. Cell Physiol Biochem. 2018; 47(2): 590-603.
27. Sun L, Yu S, Xu H, Zheng Y, Lin J, Wu M, Wang J, Wang A, Lan Q, Furnari F, Cavenee W, Purow B, Li M. FHL2 interacts with EGFR to promote glioblastoma growth. Oncogene. 2018; 37(10):1386-1398. (IF=9.867)
28. Chen Y, Liu J, Wang W, Xiang L, Wang J, Liu S, Zhou H, Guo Z. High expression of hnRNPA1 promotes cell invasion by inducing EMT in gastric cancer. Oncol Rep. 2018; 39(4):1693-1701.
29. Zhang P, Tang WM, Zhang H, Li YQ, Peng Y, Wang J, Liu GN, Huang XT, Zhao JJ, Li G, Li AM, Bai Y, Chen Y, Ren YX, Li GX, Wang YD, Liu SD, Wang JD. MiR-646 inhibited cell proliferation and EMT-induced metastasis by targeting FOXK1 in gastric cancer. Br J Cancer. 2017, 117(4):525-534. (IF=7.640)
30. Zhang Y, Wang Z, Liu J, Zhang S, Fei J, Li J, Zhang T, Wang J, Park PW, Chen Y. Cell surface-anchored syndecan-1 ameliorates intestinal inflammation and neutrophil transmigration in ulcerative colitis. J Cell Mol Med. 2017; 21(1): 13-25. (IF=5.310).
31. Xie R, Wang J, Liu X, Wu L, Zhang H, Tang W, Li Y, Xiang L, Peng Y, Huang X, Bai Y, Liu G, Li A, Wang Y, Chen Y, Ren Y, Li G, Gong W, Liu S, Wang J. RUFY3 interaction with FOXK1 promotes invasion and metastasis in colorectal cancer. Sci Rep. 2017, 7(1): 3709. (IF: 4.379).
32. Zhang M, Ma F, Xie R, Wu Y, Wu M, Zhang P, Peng Y, Zhao J, Xiong J, Li A, Cheng K, Zhang Y, Liu S, Wang J, Chen X. Srcin1 overexpression contributes to colorectal cancer growth and metastasis. Int J Oncol. 2017; 50(5): 1555-1566. (IF=5.650).
33. Xie R, Wang J, Tang W, Li Y, Peng Y, Zhang H, Liu G, Huang X, Zhao J, Li A, Gong W, Chen Y, Ren Y, Wang Y, Li G, Liu S, Wang J. Rufy3 promotes metastasis through epithelial-mesenchymal transition in colorectal cancer. Cancer Lett. 2017; 390:30-38. (IF=7.485)
34. Wu M, Wang J, Tang W, Zhan X, Li Y, Peng Y, Huang X, Bai Y, Zhao J, Li A, Chen C, Chen Y, Peng H, Ren Y, Li G, Liu S, Wang J. FOXK1 interaction with FHL2 promotes proliferation, invasion and metastasis in colorectal cancer. Oncogenesis. 2016; 5(11):e271 (IF=3.2)
35. Peng Y, Zhang P, Huang X, Yan Q, Wu W,  Xie R, Wu Y, Zhang M, Nan Q, Zhao J, Li A, Xiong J, Ren Y, Yang B, Chen Y, Liu S and Wang J. Direct regulation of FOXK1 by C-jun promotes proliferation, invasion and metastasis in gastric cancer cells. Cell Death Dis. 2016; 7(11):e2480. (IF=8.469)
36. Wu Y, Xie R, Liu X, Wang J, Peng Y, Tang W, Wu M, Zhang P, Ba Y, Zhao J, Li A, Nan Q, Chen Y, Liu S, Wang J. Knockdown of FOXK1 alone or in combination with apoptosis-inducing 5-FU inhibits cell growth in colorectal cancer. Oncol Rep. 2016 36(4):2151-9.  (IF=3.906)
37. Wu Y, Peng Y, Wu M, Zhang W, Zhang M, Xie R, Zhang P, Bai Y, Zhao J, Li A, Nan Q, Chen Y, Ren Y, Liu S, Wang J. Oncogene FOXK1 enhances invasion of colorectal carcinoma by inducing epithelial- mesenchymal transition. Oncotarget. 2016; 7(32):51150-51162.
38. Yan Q, Zhang W, Wu Y, Wu M, Zhang M, Shi X, Zhao J, Nan Q, Chen Y, Wang L, Cheng T, Li J, Bai Y, Liu S, Wang J. KLF8 promotes tumorigenesis, invasion and metastasis of colorectal cancer cells by transcriptional activation of FHL2. Oncotarget. 2015; 6(28): 25402-17.
39. Shi X, Luo X, Yan Q, Zhang W, Wu Y, Zhang M, Zhao J, Peng Y, Chen Y, Zhang Y, Chen C, Cheng T, Chen C, Liu S, Bai Y, Wang J. Suppression of KLF8 induces cell differentiation and sensitizes colorectal cancer to 5-fluorouracil. Oncol Rep. 2015; 34(3):1221-30. (IF= 3.906).
40. Zhang W, Shi X, Peng Y, Wu M, Zhang P, Xie R, Wu Y, Yan Q, Liu S, Wang J.HIF-1α Promotes Epithelial-Mesenchymal Transition and Metastasis through Direct Regulation of ZEB1 in Colorectal Cancer. PLoS One. 2015; 10(6): e0129603. (IF= 3.240).
41. Ma F, Bi L, Yang G, Zhang M, Liu C, Zhao Y, Wang Y, Wang J, Bai Y, Zhang Y. ZNF703 promotes tumor cell proliferation and invasion and predicts poor prognosis in patients with colorectal cancer. Oncol Rep. 2014; 32(3): 1071-7. (IF= 3.906).
42. Zhang W, Wu Y, Yan Q, Feng M, Shi X, Zhao Y, Peng Y, Wang J, Jiang B. Deferoxamine enhances cell migration and invasion through promotion of HIF-1α expression and epithelial-mesenchymal transition in colorectal. Oncol Rep. 2014; 31(1): 111-116  (IF= 3.906).
43. Xiong J, Lin YH, Bi LH, Wang JD, Bai Y, Liu SD. Effects of interleukin-4 or interleukin-10 gene therapy on trinitrobenzenesulfonic acid-induced murine colitis. BMC Gastroenterol. 2013; 13:165. (IF= 3.067)
44. Wu Y, Guo Z, Zhang D, Zhang W, Yan Q, Shi X, Zhang M, Zhao Y, Zhang Y, Jiang B, Cheng T, Bai Y, Wang J. A novel colon cancer gene therapy using rAAV‑mediated expression of human shRNA-FHL2. Int J Oncol. 2013; 43(5):1618-26.  (IF=5.650).
45. Zhao Y, Zhang W, Guo Z, Ma F, Wu Y, Bai Y, Gong W, Chen Y, Cheng T, Zhi F, Zhang Y, Wang J, Jiang B. Inhibition of the transcription factor Sp1 suppresses colon cancer stem cell growth and induces apoptosis in vitro and in nude mouse xenografts. Oncol Rep. 2013; 30(4):1782-92 (IF= 3.906).
46. Wang QY, Sun AM, Song J, Chen Y, Wang JD, Li CG. Cytokine tumor necrosis factor alpha induces intestinal epithelial barrier dysfunction. Cytokine, 2012; 58(2), 226-230. (IF=3.861)
47. Zhang W, Yang Y, Jiang B, Peng J, Tu S, Sardet C, Zhang Y, Pang R, Hung IF, Tan VP, Lam CS, Wang J, Wong BC. XIAP-associated factor 1 interacts with and attenuates the trans-activity of four and a Half LIM protein 2. Mol Carcinog. 2011; 50(3):199-207. (IF=4.784)
48. Zhang W, Wang J, Zou B, Sardet C, Li J, Lam CS, Ng L, Pang R, Hung IF, Tan VP, Jiang B, Wong BC. Four and a half LIM protein 2 (FHL2) negatively regulates the transcription of E-cadherin through interaction with Snail1. Eur J Cancer. 2011; 47: 121-30. (IF=9.162)
49. Ma J, Wang JD, Zhang WJ, Zou B, Chen WJ, Lam CS, Chen MH, Pang R, Tan VP, Hung IF, Lan HY, Wang QY, Wong BC. Promoter hypermethylation and histone hypoacetylation contribute to pancreatic-duodenal homeobox 1 silencing in gastric cancer. Carcinogenesis. 2010; 31(9):1552-60. (IF=4.944)
50. Guo Z, Zhang W, Xia G, Niu L, Zhang Y, Wang X, Zhang Y, Jiang B, Wang J. Sp1 upregulates the four and half lim 2 (FHL2) expression in gastrointestinal cancers through transcription regulation. Mol Carcinog. 2010; 49: 826-36. (IF=4.784)
51. Zhang W, Jiang B, Guo Z, Sardet C, Zou B, Lam CS, Li J, He M, Lan HY, Pang R, Hung IF, Tan VP, Wang J, Wong BC. Four-and-a-half LIM protein 2 promotes invasive potential and epithelial-mesenchymal transition in colon cancer. Carcinogenesis. 2010; 31: 1220-9. (IF=4.944)
52. An X, Ng SS, Xie D, Zeng YX, Sze J, Wang J, Chen YC, Chow BK, Lu G, Poon WS, Kung HF, Wong BC, Lin MC. Functional characterisation of cell cycle-related kinase (CCRK) in colorectal cancer carcinogenesis. Eur J Cancer. 2010; 46(9):1752-61 (IF=9.162)
53. Zhang W, Guo Z, Jiang B, Niu L, Xia G, Wang X, Cheng T, Zhang Y, Wang J. Identification of a functional p53 responsive element within the promoter of XAF1 gene in gastrointestinal cancer cells.  Int J Oncol. 2010; 36(4):1031-7. (IF=5.650)
54. Dai Y, Qiao L, Chan KW, Yang M, Ye J, Zhang R, Ma J, Zou B, Lam CS, Wang J, Pang R, Tan VP, Lan HY, Wong BC. Adenovirus-mediated down-regulation of X-linked inhibitor of apoptosis protein inhibits colon cancer. Mol Cancer Ther. 2009; 8(9):2762-70 (IF=6.261)
55. Li M, Wang J, Ng SS, Chan CY, He ML, Yu F, Lai L, Shi C, Chen Y, Yew DT, Kung HF, Lin MC. Adenosine diphosphate-ribosylation factor 6 is required for epidermal growth factor-induced glioblastoma cell proliferation. Cancer. 2009; 115(21):4959-72. (IF=6.860)
56. Wang J, Gu Q, Li M, Zhang W, Yang M, Zou B, Chan S, Qiao L, Jiang B, Tu S, Ma J, Hung IF, Lan HY, Wong BC. Identification of XAF1 as a novel cell cycle regulator through modulating G(2)/M checkpoint and interaction with checkpoint kinase 1 in gastrointestinal cancer. Carcinogenesis. 2009; 30(9):1507-16. (IF=4.944)
57. Dai Y, Qiao L, Chan KW, Yang M, Ye J, Ma J, Zou B, Gu Q, Wang J, Pang R, Lan HY, Wong BC. Peroxisome proliferator-activated receptor-gamma contributes to the inhibitory effects of Embelin on colon carcinogenesis. Cancer Res. 2009; 69(11):4776-83 (IF=12.701)
58. Liu Y, Yue H, Li A, Wang J, Jiang B, Zhang Y, Bai Y. An epidemiologic study on the correlation between oral Helicobacter pylori and gastric H. pylori. Curr Microbiol. 2009; 58(5):449-53. (IF=2.188)
59. Wang J, Zhang W, Zhang Y, Chen Y, Zou B, Jiang B, Pang R, Gu Q, Qiao L, Lan H, Kung HF, Wong BC. c-Jun N-terminal kinase (JNK1) upregulates XIAP-associated factor 1 (XAF1) through interferon regulatory factor 1 (IRF-1) in gastrointestinal cancer. Carcinogenesis. 2009;30(2):222-9 (IF=4.944)
60. Qiao L, Wang Y, Pang R, Wang J, Dai Y, Ma J, Gu Q, Li Z, Zhang Y, Zou B, Lan HY, Wong BC. Oncogene functions of FHL2 are independent from NF-kappaBIalpha in gastrointestinal cancer. Pathol Oncol Res. 2009;15(1):31-6. (IF=3.201)
61. Qiao L, Li GH, Dai Y, Wang J, Li Z, Zou B, Gu Q, Ma J, Pang R, Lan HY, Wong BC. Gene expression profile in colon cancer cells with respect to XIAP expression status. Int J Colorectal Dis. 2009 ;24(3):245-60. (IF=2.571)
62. Ma J, Chen M, Wang J, Xia HH, Zhu S, Liang Y, Gu Q, Qiao L, Dai Y, Zou B, Li Z, Zhang Y, Lan H, Wong BC. Pancreatic duodenal homeobox-1 (PDX1) functions as a tumor suppressor in gastric cancer. Carcinogenesis. 2008; 29(7): 1327-33 (IF=4.944)
63. Wang X, Wang J, Lin S, Geng Y, Wang J, Jiang B. Sp1 is involved in H2O2-induced PUMA gene expression and apoptosis in colorectal cancer cells. J Exp Clin Cancer Res. 2008;27:44 (IF=11.161)
64. Qiao L, Dai Y, Gu Q, Chan KW, Zou B, Ma J, Wang J, Lan HY, Wong BC. Down-regulation of X-linked inhibitor of apoptosis synergistically enhanced peroxisome proliferator-activated receptor gamma ligand-induced growth inhibition in colon cancer. Mol Cancer Ther. 2008;7(7):2203-11(IF=6.261)
65. Zhuang ZH, Tsao SW, Deng W, Wang JD, Xia HH, He H, Feng HC, Wang LD, Gu Q, Lam SK, Lin MC, Kung HF, Wong BC. Early upregulation of cyclooxygenase-2 in human papillomavirus type 16 and telomerase-induced immortalization of human esophageal epithelial cells. Gastroenterol Hepatol. 2008; 23(10):1613-20 (IF=4.029)
66. Li M, Wang J, Ng SS, Chan CY, Chen AC, Xia HP, Yew DT, Wong BC, Chen Z, Kung HF, Lin MC. The Four-and-a-half-LIM Protein 2 (FHL2) Is Overexpressed in Gliomas and Associated with Oncogenic Activities. Glia. 2008;56(12):1328-38. (IF=7.452)
67. Ding SZ, Minohara Y, Fan XJ, Wang J, Reyes VE, Patel J, Dirden-Kramer B, Boldogh I, Ernst PB, Crowe SE. Helicobacter pylori infection induces oxidative stress and programmed cell death  in human gastric epithelial cells. Infection and Immunity. Infect Immun. 2007; 75(8): 4030-9  (IF=3.441)
68. Yu LF, Wang J, Zou B, Lin MC, Wu YL, Xia HH, Sun YW, Gu Q, He H, Lam SK, Kung HF, Wong BC.  XAF1 Mediates Apoptosis Through Extracellular Signal Regulated Kinase Pathway in Colon Cancer. Cancer. 2007 ;109(10):1996-2003 (IF=6.860)
69. Zou B, Chim CS, Zeng H, Leung SY, Yang Y, Tu SP, Lin MCM, Wang J, HE H, Jiang SH, Sun YW, Yu LF, Yuen ST, Kung HF, Wong BCY. Correlation between the Single-Site CpG and Expression Silencing of the XAF1 Gene in Human Gastric and Colon Cancers. Gastroenterology, 2006; 131(6):1835-43 (IF=22.682)
70. Li XP, Li CY, Li X, Ding Y, Chan LL, Yang PH, Li G, Liu X, Lin JS, Wang J, He M, Kung HF, Lin MC, Peng Y. Inhibition of human nasopharyngeal carcinoma growth and metastasis in mice by adenovirus-associated virus–mediated expression of human endostatin. Mol Cancer Ther.  2006; 5(5): 1290-1298 (IF=6.261)
71. Gu Q, Xia HH, Wang JD, Wong WM, Chan AO, Lai KC, Chan CK, Yuen MF, Fung FM, Wong KW, Lam SK, Wong BC. Update on clarithromycin resistance in Helicobacter pylori in Hong Kong and its effect on clarithromycin-based triple therapy. Digestion  2006;73(2-3):101-6 (IF=3.216)
72. Xia HH, He H, De Wang J, Gu Q, Lin MC, Zou B, Yu LF, Sun YW, Chan AO, Kung HF, Wong BC. Induction of apoptosis and cell cycle arrest by a specific c-Jun NH2-terminal kinase (JNK) inhibitor, SP-600125, in gastrointestinal cancers. Cancer Lett. 2006; 241: 268-274  (IF=8.679)
73. Wang X, Li M, Wang J, Yeung CM, Zhang H, Kung HF, Jiang B, Lin MC. The BH3-only protein, PUMA, is involved in oxaliplatin-induced apoptosis in colon cancer cells. Biochem Pharmacol.  2006, 71(11):1540-1550 (IF=5.858)
74. Li GQ, Xia HH, Chen MH, Gu Q, Wang JD, Peng JZ, Chan AO, Cho CH, So HL, Lam SK, Hu PJ, Liang YJ, Lin HL, Berg DE, Feng ZH, Langenbach R, Wong BC. Effects of Cyclooxygenase-1 and -2 Gene Disruption on Helicobacter pyloriInduced Gastric Inflammation. J Infect Dis. 2006, 193(7): 1037 –1046 (IF=5.226)
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