杨魏，南方医科大学基础医学院/广东省人民医院（广东省医学科学院）教授，博士生导师，国家优青。2013年博士毕业于中国科学院上海生命科学研究院；2013年7月至2016年9月在中国科学院上海生物化学与细胞生物学研究所从事博士后研究工作。长期从事T细胞免疫应答与疾病相关研究工作，主要从代谢角度研究胆固醇等脂质分子及其代谢对T细胞免疫应答和肿瘤免疫的调控作用和机制。研究成果以第一和通讯作者发表在Nature（2013 & 2016）、Nature Structural & Molecular Biology （2017） 、Nature Communications（2018）和Protein & Cell (2021)等杂志。申请国内及国际发明专利8项，部分研究成果入选科技部2016年中国科学十大进展和中国科协生命科学联合体2016年中国生命科学十大进展。承担国家自然科学基金、科技部重点研发计划和广东省自然科学基金项目等各类项目6项。

免疫代谢与肿瘤免疫

Ø  Yuan J^*, Cai T^*, Zheng X^*, Ren Y^*, Qi J, Lu X, Chen H, Lin H, Chen Z, Liu M, He S, Chen Q, Feng S, Wu Y, Zhang Z^#, Ding Y^#, Yang W^#. Potentiating CD8⁺ T cell antitumor activity by inhibiting PCSK9 to promotes LDLR-mediated TCR recycling and signaling. Protein & Cell, 2021, 12(4): 240-260 (corresponding author) 

Ø  Qi J^*, Liu X^*, Yan P^*, He S^*, Lin Y, Huang Z, Zhang S, Xie S, Li Y, Lu X, Wu Y, Zhou Y, Yuan J, Cai T, Zheng X^#, Ding Y^#, Yang W^#. Analysis of Immune Landscape Reveals Prognostic Significance of Cytotoxic CD4⁺ T Cells in the Central Region of pMMR CRC. Front. Oncol., 22 Sep 2021(corresponding author)

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Ø  Yang W^*, Bai Y^*, Xiong Y, Zhang J, Chen S, Zheng X, Meng X, Li L, Wang J, Xu CG, Yan C, Wang L, Chang CCY, Chang TY, Zhang T, Zhou P, Song BL, Liu W, Sun SC, Liu X, Li BL^#, Xu C^#. Potentiating the antitumour response of CD8⁺ T cells by modulating cholesterol metabolism. Nature. 2016, 531(7596), 651-655. (^*co-first author)

Ø  Shi X^*, Bi Y^*, Yang W^*, Guo X, Jiang Y, Wan C, Li L, Bai Y, Guo J, Wang Y, Chen X, Wu B, Sun H, Liu W, Wang J, Xu C. Ca²⁺ regulates T cell receptor activation by modulating the electrostatic property of phospholipids, Nature. 2013, 493(7430), 111-115. (^*co- first author)

Ø  Yang W^*, Pan W^*，Chen S^*, Trendel N^*, Jiang S^*, Xiao F, Xue M, Wu W, Peng Z, Li X, Ji H, Liu X, Jiang H, Wang H, Shen H, Dushek O^#, Li H^#, Xu C^#. Dynamic regulation of CD28 conformation and signaling by charged lipids and ions. Nat Struct & Mol Biol, 2017, 24 (12) 1081-1092 (*co-first author)

Ø  Xiang W*, Shi R*, Kang X*, Zhang X*, Chen P, Zhang L, Hou A, Wang R, Zhao Y, Zhao K, Liu Y, Ma Y, Luo H, Shang S, Zhang J, He F, Yu S, Gan L, Shi C, Li Y#, Yang W#, Liang H#, Miao H#. Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression. Nature Communications. 2018 Jul 3;9(1):2574 (#corresponding author)

Ø  Meng X, Liu X, Guo X, Jiang S, Chen T, Hu Z, Liu H, Bai Y, Xue M, Hu R, Sun SC, Liu XL, Zhou P, Huang X, Wei L, Yang W & Xu C. FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells. Nature. 2018, 564(7734), 130-135.