研究方向：1.特殊环境因素对机体的损伤与调控机制。2. 细胞应激与线粒体蛋白质稳态机制研究。3. 细胞外泌体与肿瘤关系的研究。
主持的部分基金项目
1. 国家自然科学基金，哮喘过敏介质信号转导的离子通道机制。1995-1997
2. 国家自然科学基金，离子通道参与温敏神经元信号转导的分子机制。2000– 2002
3. 国家自然科学基金海外合作项目，NO和离子通道信号系统对神经可塑性调控的分子机制。2000– 2002
4. 国家自然科学基金，用SSH和单细胞RT-PCR技术研究热适应差显基因与功能。2004-2006
5. 国家重点基础研究发展计划（973计划）分题，高原低氧等环境因素损伤适应机理与干预措施。2006-2011
6. 国家自然科学基金， TRP家族和磷脂酰肌醇的易位及在膜脂筏区的相互作用参与中性粒细胞极性化得研究。2010-2012
7. 国家重点基础研究发展计划（973计划）课题，适度低氧对健康促进作用的机制。
8. 国家自然科学基金，低氧预适应中Hsp90分子伴侣功能对相互作用底物蛋白的折叠、降解分选机制及作用。2013-2016
9. 国家自然科学基金，Hsp90α调控Bclaf1蛋白稳定性及其在低氧适应中的作用机制研究。2017-2020
10. 国家自然科学基金，低氧适应中Bcl-2相关转录因子1调控HIF-1α转录机制的研究。201801-201812
11. 国家自然科学基金，低氧环境下Hsp90对BCLAF1相关脂质代谢通路转录调控机制研究。2020-2023
12.国家自然科学基金重点项目，低氧适应中热休克蛋白90对线粒体蛋白质稳态的影响及调控机制。2022-2026
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13.Chen J, Mao K, Yu H, Wen Y, She H, Zhang H, Liu L, Li M, Li W, Zou F. p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's disease. J Neuroinflammation. 2021 Dec 20;18(1):295. （小类2区，8.322 )
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