王莺 南方医科大学基础医学院肿瘤研究所 副研究员 博士生导师，广东省精准医学应用学会妇科肿瘤分会常务委员，中国研究型医院学会细胞外囊泡研究与应用专业委员会委员。2009年博士毕业于湖南大学有机化学专业，2008年以访问学者身份在Emory大学深造，2010年入职南方医科大学基础医学院肿瘤研究所。主要研究方向是新型仿生抗癌药物输送系统应用于原位卵巢癌、脑胶质瘤和乳腺癌等的研究，植物外泌体为药物载体对多种肿瘤的治疗，包括药物体系对肿瘤细胞水平的性能评价、药物体内动力学研究等，关注于联合治疗方案设计与运用等，并长期与临床科室的合作，先后与南方医院超声科、珠江医院妇产科、神经外科等合作，取得了较好的研究进展。先后以通讯作者在Advanced Functional Materials，Nano Letters, Bioactive materials, Advanced Science等国际一流期刊发表论文，发表第一作者或通讯作者相关SCI论文23篇，获得国家发明专利授权 6项。先后主持多项广东省自然科学基金，主持多项国家自然科学基金，并作为主要骨干参与5项国家自然科学基金项目，并获得省级科学技术一等奖1项,二等奖1项。

仿生药物输送系统应用于原位卵巢癌、脑胶质瘤和乳腺癌等的治疗

1. Jiamao Luo, Xinxian Zhong, Yingming Peng, Chenyuan Hao, Xiaomei Liang, Yulu Yang, Xiubo Shi, Xuncai Chen, Xiao Yi, Xiaoxuan Li, Jianhua Wu, Jinheng Li, Qian Xiao, Chentian Wu, Ruojing Lu, Yao Pan, Xuejiao Wang, Jun-Bing Fan*, Yifeng Wang*, Ying Wang*. Self-anti-angiogenesis nanoparticles enhance anti-metastatic-tumor efficacy of chemotherapeutics. Bioactive Materials. 2022, 13, 179-190.

2. Qian Xiao, Wei Zhao, Chentian Wu, Xuejiao Wang, Jianping Chen, Xiubo Shi, Suinan Sha, Jinheng Li, Xiaomei Liang, Yulu Yang, Yingming Peng, Haoyan Guo, Ying Wang*, Jun-Bing Fan*. Lemon-Derived Extracellular Vesicles Nanodrugs Enable Efficiently Overcome Cancer Multidrug Resistance by Endocytosis-Triggered Energy Dissipation and Energy Production Reduction. Advanced Science. 2022, 2105274

3. Wenbo Niu, Qian Xiao, Xuejiao Wang, Junqiao Zhu, Jinheng Li, Xiaomei Liang, Yingming Peng, Chentian Wu, Ruojing Lu, Yao Pan, Jiamao Luo, Xinxian Zhong, Haoqi He, Zhili Rong, Jun-Bing Fan,* Ying Wang*. A biomimetic drug delivery system by integrating grapefruit extracellular vesicles and doxorubicin-loaded heparin-based nanoparticles for glioma therapy. Nano Letters. 2021. 21,3 1484–1492

4. Huajian Chen#, Qizhi Luo#, Jihui Wang#, Haoqi He, Wanxian Luo, Li Zhang, Qian Xiao, Taoliang Chen, Xiangdong Xu, Wenbo Niu, Yiquan Ke^*, Ying Wang* Response of pH-sensitive Doxorubicin nanoparticles on complex tumor microenvironments by tailoring multiple physicochemical properties. ACS Applied Materials & Interfaces. 2020, 12, 22673-22686.

5. Li Zhang#, Shiyu Zhang#, Huajian Chen, Yu Liang, Bingxia Zhao, Wanxian Luo, Qian Xiao, Jinheng Li, Junqiao Zhu, Chao Peng, Yaru Zhang, Zhe Hong, Ying Wang*, Yingjia Li*. An acoustic/thermo-responsive hybrid system for advanced doxorubicin delivery in tumor treatment. Biomaterials Science. 2020,8, 2202-2211.

6. Yifeng Wang ^#, Lin Tong ^#, Jianguo Wang, Jiamao Luo, Jiao Tang, Lijuan Zhong, Qian Xiao , Wenbo Niu, Jinheng Li, Junqiao Zhu, Huajian Chen, Xin Li^*, Ying Wang* cRGD-functionalized nanoparticles for combination therapy of anti-endothelium dependent vessels and anti-vasculogenic mimicry to inhibit the proliferation of ovarian cancer. Acta Biomaterialia. 2019, 94, 495-504.

7. Wanxian Luo, Ge Wen, Li Yang, Jiao Tang, Jianguo Wang, Jihui Wang, Shiyu Zhang, Li Zhang, Fei Ma, Liling Xiao, Ying Wang*, Yingjia Li*. Dual-targeted and pH-sensitive Doxorubicin Prodrug-Microbubble Complex with Ultrasound for Tumor Treatment. Theranostics 2017, 7(2): 452-465.

8. Dongxiao Wang, Wanxian Luo, Ge Wen, Li Yang, Shaofu Hong, Shiyu Zhang, Jianxin Diao, Jianguo Wang, Hongqin Wei, Yingjia Li*, Ying Wang*. Synergistic effects of negative-charged nanoparticles assisted by ultrasound on the reversal multidrug resistance phenotype in breast cancer cells. Ultrasonics Sonochemistry 34 (2017) 448–457.

9. Jihui Wang, Yuantao Yang, Yonghong Zhang, Min Huang, Zhenjun Zhou, Wanxian Luo, Jiao Tang, Jianguo Wang, Qian Xiao, Huajian Chen, Yingqian Cai, Xinlin Sun*, Ying Wang*, Yiquan Ke*. Dual-Targeting and Reself-Assembly Heparin-Based Nanoparticles for Combining Anti-Proliferation and Anti-Angiogenesis Therapy of Glioma. Advanced Functional Materials, 2016, 26(43): 7873-7885.

10. Ying Wang^*, Yingjia Li, Dongxiao Wang, Shaofu Hong, Jianguo Wang, Baoping Xie, Qianbing Zhang, Xingmei Zhang, Hongfen Shen, Qian Xiao. Response of heterogeneous cancer cells on targeted nanoparticles. Nanomedicine: Nanotechnology, Biology, and Medicine. 2016, 12, 2127-2137.